You need reliable, protocol-driven data, but sites can’t focus on quality when bogged down with administrative details and manual tasks. There’s an eSource solution that collects source data in real time and enables remote monitoring. And makes it all easier. It’s clearly CRIO.
What Is CRIO’s eSource Solution and How Does It Work?
CRIO is an intuitive eSource solution that collects data directly at the point of patient interaction, lightening site burden, standardizing data capture across sites, and enabling real-time remote monitoring for sponsors and CROs. Created by a team of clinical research experts who understand what sites need to perform better, it’s built to make trials run seamlessly from the start:
Fully configurable and scalable templatesstandardize data capture
Real-time data access enables remote monitoring and collaboration
Easily accessible reporting and query capabilities enhance data quality and site performance
A connected ecosystem supporting essential data collection activities streamlines workflows
See CRIO in Action
How Does CRIO Improve Clinical Trial Performance for Sites, Sponsors, and CROs?
I think of Central eSource® as the next evolution in clinical trial efficiency, similar to the shift toward central IRBs and central labs. It ensures high-quality data by standardizing critical data points, yet empowers sites to configure the system to align with their own local practices. Central eSource speeds up study startup considerably. Everyone benefits.
Takoda Roland, Associate Vice President of Customer Success, Sitero
As a tech-enabled, virtual CRO, we have incorporated CRIO as a core technology to deliver streamlined and compliant data for our sponsor clients. Our digital-first design philosophy, combined with CRIO’s site-centric approach, deliver unique value and faster timelines across virtual, hybrid and traditional study structures.
Joel Morse, CEO, Curavit
CRIO’s Reviewer interface is intuitive and easy to use, and with direct data capture, sponsors have a cost effective tool to take more clinical trial oversight in house.
David Goffredo, Associate Director Clinical Projects, RxSight, Inc.
In research, one error can cause a lot of bad consequences like an audit, loss of business, etc. With CRIO, I know I have a much lower chance of something like that happening. I can go to sleep at night knowing we have quality under control. This is my livelihood, so there is no price tag to that peace of mind.
Dr. James Clark, Chief Medical Officer, Alcanza
I highly recommend sites, sponsors and CROs implement CRIO across their trials. It’s a powerful, purpose-built clinical research tool that ensures protocol compliance upfront.
Dr. Elena Christofides, CEO, Endocrinology Associates
Swapping from paper to e-source always has its challenges but the CRIO team have been with us throughout journey; actively listening and guiding us on next steps.
Melanie Smyth, Senior Director Clinical Operations, hVivo
CRIO is a clinical research platform purpose-built for the way modern trials actually run. At its core, CRIO replaces paper-based source documentation with intuitive electronic data capture directly at the point of patient interaction — reducing site burden, improving data quality, and giving sponsors and CROs real-time visibility into what’s happening across their studies. Beyond eSource, CRIO connects the full site workflow: eConsent, eRegulatory, and CTMS all live within a single platform. The result is a more efficient site, cleaner data, and faster trials for everyone involved.
Traditional eSource puts the burden on individual sites to build and maintain their own data collection templates — a time-consuming process that leads to inconsistent data across a study. CRIO’s Central eSource® flips that model. Sponsors and CROs create a single, standardized source template centrally and publish it to all investigator sites at once. Sites can configure it to meet local requirements and preferences, but the core data fields stay consistent — ensuring every data point is collected the same way, everywhere. The outcome is faster study startup, less site-level configuration work, and the kind of data standardization that makes monitoring and analysis dramatically more efficient.
Sites that run on CRIO spend less time on paperwork and more time on patients. Visit templates guide coordinators through each protocol requirement in real time, reducing the back-and-forth that comes with paper source documents. Regulatory binders, consent forms, and patient records are all managed within the same platform — no more hunting across systems or filing cabinets.
Yes. CRIO integrates with leading EDC platforms including Veeva Vault EDC and Medidata Rave, allowing data captured in CRIO to flow directly into EDC — eliminating manual transcription and the errors that come with it. For sites, that means less data entry work after every visit. For sponsors and CROs, it means faster access to clean data, fewer queries, and a significantly reduced need for source data verification.
The outcomes speak for themselves. Sites using CRIO have seen 40% higher patient enrollment, driven by more efficient visit workflows and reduced coordinator burden. Data quality improves measurably — CRIO users report 20% fewer protocol deviations and 40% faster time to EDC entry. For sponsor studies using Central eSource®, sites reach first patient in (FPI) 30–40 days faster than traditional approaches.
CRIO is the leading eSource and clinical trial management platform, purpose-built for research sites and trusted by sponsors and CROs worldwide. Through intuitive, integrated eSource and CTMS technology created by clinical research experts, CRIO helps sites collect reliable, protocol-driven data at the point of patient interaction while enabling sponsors and CROs to monitor remotely in real time. The results are 40% higher enrollment, 40% faster startup, 40% fewer protocol deviations, and a 90% increase in monitoring productivity. The eSource solution built for sites and better for your trials is clearly CRIO.
